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Cardio Program of Excellence in Glycosciences
 

Highlights​

Worldwide patent filed by Dr. Subroto Chatterjee. On May 3, 2013, Dr. Chatterjee filed for a patent on the use of glycosyltransferase inhibitors to ameliorate cardiac hypertrophy. The patent is currently in the national phase.


Upcoming Seminars

Cardio PEG Lab Meetings

(Physiology 612, 9.30-11)

This meeting is suspended over the summer. Watch this space for updates.


Cardio PEG Retreat

(Mt Washington Conference Center)

July 15th, Register by July 5th @ CardioPEG Registration

Schedule: Final Rev PEG 2016 Retreat Sched[1].pdfFinal Rev PEG 2016 Retreat Sched[1].pdf


Glycobiology Interest Group

This meeting is suspended over the summer. Watch this space for updates.

Upcoming Classwork

January 2017: Fundamentals of Glycobiology

July 2017: Techniques in Glycobiology


Overall Program Goals:

The overall goals of the CardioPEG are to elucidate the molecular roles of glycoconjugates in the mechanisms that protect the heart from acute ischemic injury, or that lead to cardiomyopathies, ischemic injury, and heart failure. The PEG is designed to work closely with local cardiologists to not only educate them about the importance of glycoconjugates to cardiovascular disease, but to reciprocally educate glycoscientists about cardiac physiology.  By design, our team will concomitantly investigate the roles of different classes of glycoconjugates. This team design was deliberate for two reasons: 1) The focus on mechanisms leading to myocardial infarction, ischemic injury and heart failure will engender broad ranging interactions and interplay between the various projects and cores, since the roles of distinct glycoconjugates in cardiovascular disease occur at different places in the pathways involved; and 2) A major goal of this PEG is to train the next generation of glycoscientists and to provide them with the knowledge and skills to perform glycoscience research at the highest level. This goal can only be met by having a cadre of outstanding glycoscientists on the team, who each bring to the table cutting‐edge expertise on each of the types of glycoconjugates important to the research mission of NHLBI.

The Glycoconjugates and Cardiovascular Disease PEG is comprised of 5 projects, a Shared Resources Core, and an Educational Core.​

Projects include:

Project 1: Crosstalk Between O-GlcNAcylation and Phosphorylation in Diabetic Cardiomyopathy.

PI Gerald W. Hart

Project 2: O-GlcNAc and Cardioprotection.

PI Natasha E. Zachara

Project 3: Glycoprotein involvement in cardiac fibroblast-myocyte communication.

PI Jenny Van Eyk, co-PI David Graham

Project 4: Roles of Platelet Glycoproteins and Glycans on Platelet Reactivity and Cardiovascular Disease.

PI Hui Zhang

Project 5: Glycosphingolipids ,Glycosyltransferases and Cardiovascular disease.

PI Subroto Chatterjee

The Education Core is providing three courses, with both didactic and hands on training, which are designed to train future leaders in glycoscience research. 

Research Cores: The goal of the research cores is to support projects in the PEG and to support projects in the research community whose goals are closely aligned with those of the NHLBI.

  • C1: Mass Spectrometry and Analytical Biochemistry

  • C2: NMR

  • C3: Chemistry

  • C4: O-GlcNAc Resources

  • D: Myocyte Isolation and Myocyte and Cardiac Physiology​​​​

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