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Cardio Program of Excellence in Glycosciences

Highlights​

Worldwide patent filed by Dr. Subroto Chatterjee. On May 3, 2013, Dr. Chatterjee filed for a patent on the use of glycosyltransferase inhibitors to ameliorate cardiac hypertrophy. The patent is currently in the national phase.


Upcoming Seminars

Cardio PEG Lab Meetings

(Physiology 612, 9.30-11)

This meeting is suspended over the summer. Watch this space for updates.


Cardio PEG Retreat

(Mt Washington Conference Center)

July 15th, Register by July 5th @ CardioPEG Registration

Schedule: Final Rev PEG 2016 Retreat Sched[1].pdfFinal Rev PEG 2016 Retreat Sched[1].pdf


Glycobiology Interest Group


This meeting is suspended over the summer. Watch this space for updates.

Upcoming Classwork

January 2017: Fundamentals of Glycobiology

July 2017: Techniques in Glycobiology

News and Noteworthy Items

In the News:

Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016;126(2):405–408. doi:10.1172/JCI85905.

Congratulation to Jungfeng Ma (Project 1), whose paper was chosen by the JBC as one of the best of 2015.O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function. December 4, 2015 The Journal of Biological Chemistry, 290, 29141-29153.doi: 10.1074/jbc.M115.691741

Congratulations to CardioPEG Graduate Student Jennifer Groves who was awarded a Poster Prize at the VIIth International Symposium on Heat Shock Proteins in Biology and Medicine (November 2015).

Congratulations to Michael McCartin who received a PURA award to study "Characterization of a Novel Cardioprotective Mechanism: O-GlcNAc Regulated Autophagy" (November 2015)

Congratulations to CardioPEG Graduate Student Jennifer Groves who was awarded an NRSA from the National Institute of Aging (October 2015).

Congratulations to CardioPEG fellows Marissa Martinez Ph.D. and Christine Jelinek who won awards for their Poster and Oral presentations at the Inter-PEG meeting (April, 2015).

Christine Amuzie was awarded supplemental training grant by NIH/NHLBI for 2013-2015. The award will support her predoctoral research, "An Exploration of the Role of lyso-Glycosphingolipids in Atherosclerosis".

Scientists at Johns Hopkins Come Closer to Eliminating Heart Disease (Apri, 2014) Scientists at Johns Hopkins University may be one step closer to eradicating debilitating heart diseases in humans, particularly those caused by excessive buildup of cholesterol. (The Daily Beast)

Arsonists and Firefighters: The Perpetual Inflammatory Civil War for Survival (April 2014) In this issue of Circulation, Chatterjee et al. describe an additive or alternative experimental approach to statin therapy. (Circulation)

John​s Hopkins Scientists Alter Fat Metabolism in Animals to Prevent Most Common Type of Heart Disease. Working with mice and rabbits, Johns Hopkins scientists have found a way to block cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number one cause of death in humans. The National Heart, Lung, and Blood Institute supports this research. (April, 2014)

Congratulations to Puchong Thirawatananond who received a 2013-2014 Provost's Undergraduate Research Award to study the molecular changes in the murine renal system in response to a high fat and cholesterol diet.

Worldwide patent filed by Dr. Subroto Chatterjee. On May 3, 2013, Dr. Chatterjee filed for a patent on the use of glycosyltransferase inhibitors to ameliorate cardiac hypertrophy. The patent is currently in the national phase.

July 2013: Fellow Kamau Fahie Ph.D. was awarded an American Heart Foundation fellowship to study the role of O-GlcNAc in autophagy

March 2013: GCF Fellow, Koen Raedschelders, won the US HUPO Post-doctoral poster award for his presentation "Potential Role of O-GlcNAc in Aortic Aneurysm: Preliminary Data on TGFb Signaling".
 
February 2013: Natasha Zachara and Lara Mahal will be co-organizing the "Frontiers in Glycobiology Theme" at the ASBMB Annual Meeting, San Diego 2014.
 
December 2012: This years GCF Fellow is Albert Lee, from Natasha Zachara's Laboratory, who will investigate the role of O-GlcNAc regulated arginine methylation in survival signaling.
 
October 2012: Pingbo Zhang’s (Project 3, Core C1) work was nominated as one of the Top 10 research advances for 2012 by the American Heart Association, Functional Genomic and Translational Biology Council. Zhang P, Ji W, dos Remedios CG, Kirk JA, Kass DA, Van Eyk JE*, Murphy AM* (*equal), Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation, In press.
 
September 2012: Congratulations to Shuang Yang (Project 4, Core C1), who was awarded third prize in at the 11th World Conference of HUPO for his presentation “Glycomics analysis using chemical immobilization of glycans, solid-phase glycan modifications, and tandem mass spectrometry”.
 
August 2012: We are pleased to announce that we have recruited three outstanding scientists to join the CardioPEG External Advisory Committee. The goal of this committee is to assess our progress and accomplishments, and to provide constructive criticism to ensure that our research is of the highest quality.
  • Anne Dell Ph.D. (Imperial College): A world leading researcher who specializes in the detection and analysis of glycans.
  • Michael Pierce Ph.D. (Complex Carbohydrate Research Center): A glycobiologist who has been a leader in the roles of glycosylation and glycosyltransferases in disease.
  •  Richard Shannon M.D. (University of Pennsylvania): A world leader in cardiovascular research, who specializes in studies which integrate an understanding of myocardial metabolism and cardiac function.

June, 2012: Jenny Van Eyk (Project 3, Core C1) was one of five recipients of the prestigious David M Levine Excellence in Mentoring Award.

May 2012: Congratulations to Roger Henry (Project 2) who was awarded a PURA Award to investigate: The Sweet Side of Cell Survival: A Model of O-GlcNAc Mediated Apoptosis Inhibition.

May 2012: Congratulations to Srona Sengupta (Project 2), who won the William D. McElroy Award (JHU Department of biology) for her undergraduate research "O-GlcNAc, A Novel Paradigm for Regulating Stress-Induced Signal Transduction Pathways".
 
April 2012: Congratulations to Srona Sengupta (Project 2), who won tUndergraduateate Student Poster Award and the "Best Poster in the Glycobiology Theme" at this years ASBMB for her work "O-GlcNAc, A Novel Paradigm for Regulating Stress-Induced Signal Transduction Pathways".
 
April 2012: Reaching the Next Generation: Natasha Zachara Ph.D. gave two seminars to “Women Serious About Science” on April 17th, 2012 at tBaltimoreore Polytechnic Institute - focusing on the many roles of Glycans in Biology.
 
Glyco-Cardio Post-Doctoral Fellow Announced

The 2012 Glyco-Cardio Post-Doctoral Fellow is Dr Raedschelders, from Jenny Van Eyk’s Lab, who will "Investigate Maladaptive O-Glycosylation Signaling in Aortic Aneurysm”.
 
 
February 26, 2012:  Keith & Russ (KTEP,  NPR member station in El Paso) talk to C. Allen Bush (Core C2, NMR Core). Dr Bush studies carbohydrates, and in this program he’ll explain how carbohydrates are crucial in cell interaction, and how they can be helpful in developing polysaccharide vaccines for bacterial diseases.
 
Two programs of excellence in glycosciences, funded by the NHLBI, to be established at Johns Hopkins University
 
 

Awards to CardioPEG trainees in 

2013-2014:

Shuang Yang, Travel Award, 22nd International   Symposium on Glycoconjugates, Dalian, China.


Kamau Fahie, American Heart Association Post-Doctoral Fellowship


Shuang Yang, Poster Award, NIH & FDA Glycosciences Day, Bethesda, MD.


Jing Chen, Travel Award. Glycobiology Society Annual Meeting, St. Petersburg, Florida.


Kamau Fahie, Travel Award, Glycobiology Society Annual Meeting, Sr. Petersburg, Florida


Shisheng Sun, Travel Award. Glycobiology Society Annual Meeting. St. Petersburg, Florida.


Jing Chen, Travel Award. MSACL. San Diego, CA.


Robert Harlan,  Travel Award. MSACL. San Diego, CA.


Jennifer Groves
, Travel Award, Experimetnal Biology, San Degio, CA



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