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Cardio Program of Excellence in Glycosciences










​Gerald Hart Ph.D.

DeLamar Professor

Director of Biological Chemistry

Address:
JHU School of Medicine
725 N. Wolfe St.
515 WBSB
Baltimore, MD 21205

Contact:
Office Phone:410-614-5993
Lab Phone:410-614-1265
Fax: 410-614-8804
Email: gwhart@jhmi.edu
Website: Hart Lab

HartCV_2011.pdfHartCV_2011.pdf​​​​​

Project 1

Crosstalk Between O-GlcNAcylation and Phosphorylation in Diabetic Cardiomyopathy

O-GlcNAcylation is unique amongst all forms of protein glycosylation in that it occurs nearly exclusively in the nucleus and cytoplasm of cells, rivaling phosphorylation in abundance and in cycling on and off proteins in response to nutrients and stress. O-GlcNAcylation has extensive crosstalk with it to regulate signaling, transcription and cytoskeletal functions in response to nutrients. It is now clear that excessive O-GlcNAcylation, resulting in dysregulated gene expression, and abnormal signaling underlies nutrient toxicity (both glucose toxicity and lipid toxicity) present in diabetes. These studies are elucidating molecular mechanisms of O-GlcNAc’s roles in diabetic cardiomyopathy, and will likely lead to unexpected and novel treatment paradigms.

Highlights​

Recent Publications 

1. Jeffrey R. Erickson, Laetitia Pereira, Lianguo Wang, Guanghui Han, Amanda Ferguson, Khanha Dao,

2. Ronald J. Copeland, Florin Despa, Gerald W. Hart, Crystal M. Ripplinger, and Donald M. Bers (2013) Diabetic Hyperglycemia activates CaMKII and Arrhythmias by O linked Glycosylation. Nature 502 (7471): 372-6. PMCID: PMC3801227

3. Partha S. Banerjee, Gerald W. Hart*, and Jin Won Cho* (2013) Chemical Approaches to Study O-GlcNAcylation. Chemical Society Reviews 42(10):4345-57. *Co-Corres. Authors. PMCID: PMC3641162

4. Ronald J. Copeland, Guanghui Han, and Gerald W. Hart (2013) O-GlcNAcomics – Revealing Roles of O-GlcNAcylation in Disease Mechanisms and Development of Potential Diagnostics. Proteomics Clinical Applications  May 3. doi: 10.1002/prca.201300001. PMCID: PMC3883918

 5. Ramirez-Correa, G.A, Ferrando, IM, Hart, GW, Murphy, A. (2013) Detection of O-GlcNAc Modifications on Cardiac Myofilament Proteins. Methods Mol. Biol. 1005, 157-168. Indexed for Medline.

6. Gerald W. Hart (2013) Nutrient Regulation of Immunity: O-GlcNAcylation Regulates Stimulus-Specific NF-kB–Dependent Transcription. Science Signaling 6 (290), pe26. Free full text.

7. Richard D. Semba, Hu Huang, Gerard A. Lutty, Jennifer E. Van Eyk, Gerald W. Hart (2013)  The Role of O-GlcNAc Signaling in the Pathogenesis of Diabetic Retinopathy. Proteomics – Clinical Applications In press.Junfeng Ma and Gerald W. Hart (2013) Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev. Proteomics 10, (4) 365-80. PMCID in process.

8. Vincent C. Hascall, Aimin Wang, Markku Tammi, Sanna Oikari, Raija Tammi, Alberto Passi, Davide Vigetti, and Gerald Hart (2014) The Dynamic Metabolism of Hyaluronan Regulates the Cytosolic Concentration of UDP-GlcNAc. Matrix Biology In Press.

9. Junfeng Ma and Gerald W. Hart (2014)  O-GlcNAc profiling: from proteins to proteomes. Clinical Proteomics 2014 11:8. PMCID in process.

10. Stéphan Hardivillé and Gerald W. Hart (2014) Nutrient Regulation of Transcription, Signaling, and Cell Physiology by O-GlcNAcylation. Cell Metabolism (Invited Review) In press.

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