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Cardio Program of Excellence in Glycosciences










Jennifer Van Eyk
Faculty

Address:
JHU-Bayview Proteomics Center
5200 Eastern Avenue
Mason F. Lord Building, Center Tower
Room 602
Baltimore, MD 21224

Contact:
Phone: (410) 550-8510
Fax: (410) 550-8512
E-mail: jvaneyk1@jhmi.edu

VanEyk_Biosketch_Final-march-2012.docVanEyk_Biosketch_Final-march-2012.doc
















David R Graham, Ph.D.

Assistant Professor

Address:
Department of Molecular and
Comparative Pathobiology
Johns Hopkins University School of Medicine
731 N. Broadway, BRB 835,
Baltimore, MD, 21205,

Contact:
Phone: (410)-955-9770
Fax: (410)-955-9823
Email: Dgraham@jhmi.edu

Mar-2012-CV-Graham.docxMar-2012-CV-Graham.docx

Project 3

Glycoprotein involvement in cardiac fibroblast-myocyte communication
The link between ROS and myocyte cell death is well established during myocardial infarction (MI). However, little is known about perturbations in cardiac fibroblast-myocyte interplay under sub-lethal conditions of ROS, a time when these cells activate their protective molecular pathways. Although critical, even far less is known about the enrivonment-cell surface interface (ECI) and how it responds to stress. We will examine the spectrum of perturbations in the secretory pathways and cell surface glycoproteomes of cells stressed with ROS. The data generated will provide new insights and provide potential therapeutic targets. Furthermore, alterations to the composition of the secretome and the identification of the key regulatory proteins or glycans involved in fibroblast proliferation, differentiation and myocyte survival opens up the possibility for the administration of an “off the shelf” therapy. Detection of circulation glycoproteins that are secreted from the heart during sub-lethal injury could translate to a myocardial ischemia diagnostic allowing earlier intervention reduced myocardial cell death and reduced risk of development of heart failure.

Highlights​

Pingbo Zhang's work was nominated as one of the top 10 research advances for 2012 by the American Heart Association Functional Genomic and Translational Biology Council. Pingbo's paper "Reaction ion monitoring to identify site-specific troponin 1 phosphorylated residues in the failing human heart" is in press in Circulation. (Project 3) 

The CardioPEG published 26 papers in 2012. See News and Publications for a complete list.



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